Deep proteomics technology recently became robust for high-accuracy clinical R&D but data analysis remains its Achilles heel. The limitation is no longer mass accuracy but signal-to-noise, especially for valuable low-abundance peptides. The solution requires a non-trivial understanding of the technical problem. Modern complex datasets really comprise two distinct subsets -- low-noise and high-noise -- requiring opposing analysis tradeoffs. Most proteomics software tools are tuned for clean spectra from abundant peptides, because they’re easier to demo and sell to mass spec novices who make up most of the market, but they actually worsen results from valuable noisy spectra. Meanwhile, workflows developed for noisy data from older instrumentation, which need updating because many necessarily over-exploited secondary parameters (especially ‘dCn’) that helped then but hurt now, lost favor because their results ‘looked’ worse for clean spectra, especially when used as-is on data from modern instruments. The net effect is, demo analyses can look near-perfect but results for critical low-abundance peptides can seem almost random, with most researchers having little idea why. . .
World Leaders In Providing A Customizable, Integrated Platform for Computational Proteomics Research
Start to appreciate the evolution of the SORCERER™GEMYNI™ software platform today with The Johns Hopkins biostatistics group
which offers an excellent introductory series of data science classes, available for FREE on Coursera.com
The SORCERER™ Enterprise is designed for Labs that have one or more high-throughput mass spectrometers. SORCERER™ Enterprise comprises of three major components integrated in a single turnkey platform: a high-performance blade server, an expandable disk storage subsystem and the SORCERER™ Proteomics Edition workflow software.
The SORCERER™ 2 is a mainstream product for most proteomic labs - those with frequent, but not continuous high-throughput needs. It is well suited for multi-vendor modern mass spec instruments and powerful enough to run the most rigorous algorithms needed for successful pathway proteomic studies.
The SORCERER-V integrated data appliance (iDA) is specifically designed to meet the needs of the mainstream mass spec lab and position researchers for the age of custom developed digital biology. SORCERER-V is positioned to become the industry standard entry point for smaller labs with initially lower-throughput needs. This product offering is designed to help bridge the digital paradigm shift gracefully, by using the PC or laptop of your choice (*with minimum system requirements) to “simulate” a scaled down, but otherwise fully functional SORCERER iDA on a network, with a full proteomics search engine and workflow.Learn more ...
View Our Online Tutorials
Sage-N Research is now offering online tutorials to not only show the ease of use with our GEMYNI platform on SORCERER, but to give you the tools that will open up a whole new world of what you can do with your SORCERER. See our blog here:"SORCERER Support How To's" that include these online videos
Sage-N Research is committed to the field of high-throughput proteomics. We regularly share our views and opinions on our blog at www.Proteomics2.com as well as educational material about the latest developments in the field. You can also find helpful copies of our CARE Notices that keep you informed about software updates.