Was this article helpful?Proteomics would be ten times more successful if results are precise and trustworthy instead of imprecise or irreproducible. We explained precise raw spectra analysis [click here] using...
Was this article helpful?We recently discovered a surprisingly fast and robust method for raw spectra analysis (RSA). For the first time, it allows clinically important LAMPs (low abundance modified peptides)...
Was this article helpful?Tandem mass spectrometry (MSMS) is a revolutionary game-changer in a changing world. But it’s being held back by weak math and computing, the foundation of the new...
Was this article helpful?The fixable reason why proteomics has little clinical impact — it’s big data mis-analyzed by small PCs using faulty analytics. Here we explain how proteomics has been...
Was this article helpful?“Data is not information, information is not knowledge, knowledge is not understanding, understanding is not wisdom.” — Clifford Stoll How do you tell the world’s best minds...
Was this article helpful?You can’t solve Sudoku with statistics. Same with proteomic peptide identification, it turns out. Current workflows contain the subtle math bug of using statistical models too early,...
Was this article helpful?Let’s say you have some data-points (x,y) in a file. Without looking, you can force a linear regression and calculate a slope. Or you can blindly fit...
Was this article helpful?“Data analysis”, often trivialized by those who don’t understand deep data, can vary from trivial to extremely difficult. Analyzing mass spectrometry (MS) data is fundamentally solving math...
Was this article helpful?While “1.0” focused on instrumentation, “Proteomics 2.0” — aka Precision Proteomics — is about application, particularly for translational clinical research. As such, the emphasis shifts from acquisition...
Was this article helpful?Proteomics mass spectrometry holds unlimited potential for translational “bench-to-bedside” medical research, but until now it lacked 3 must-haves: robustness, sensitivity, and verifiability. Clinical impact requires dependable analysis...